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KMID : 0360419730090020009
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Korean Journal of Pharmacology
1973 Volume.9 No. 2 p.9 ~ p.16
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Effect of Ginseng Saponin on the General Behavior in Rats
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Abstract
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It is said thst the chinese medicine, Ginseng root has some effects on the central nervous system.
Ginseng saponin was prepared from Ginseng methanol extract and its effect on general behavioral activity was studied in rats.
Each experimental group was composed of 8 rats. The behavioral activity of rats was observed in terms of 7 components i.e. sleeping, lying, grooming, rearing, walking, eating and drinking.
In each group, total duration of behavior-observation was 2 hours, which were devided into four 30 min-intervals. The behavior-observation was done 10 times for each interval, so total number of observation was 40 times throughout 2 hours.
Ginseng saponin showed central nervous system stimulant action in reduced sleeping component and in increased activity components.
From the results of this study, it is suggested that Ginseng saponin inhibits the extrapyramidal action of chlorpromazine.
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